Reliable detection of NGT products is possible and essential for transparency and consumer trust, say researchers
The first policy briefing from DARWIN, the EU-funded project for detecting gene-edited organisms (NGTs), focuses on the analytical detection of products derived from new GM techniques (new genomic techniques, NGTs). Gene-editing technologies such as TALENs and CRISPR/Cas, present regulatory challenges regarding EU standards for transparency, traceability and labelling.
The policy brief reaffirms that PCR-based methods (qPCR, dPCR) remain highly effective for detecting genetically modified organisms (GMOs) and can be adapted to detect NGTs when prior knowledge of the modification exists. The document also presents findings from a recent study by DARWIN researchers that has demonstrated the effectiveness of combining whole genome sequencing, public genome databases, and machine learning to identify a minimal set of unique genetic markers or “genetic fingerprint”. This fingerprint enables the unambiguous identification of an NGT line.
Importantly, this fingerprint can be detected using both untargeted and semi-targeted analytical approaches, showing strong potential for the identification of NGT modifications. While these methods are not yet implemented in official GMO control frameworks and therefore require further development and validation, the approach represents a significant step toward ensuring the reliable detection and traceability of gene-edited organisms.
These recommendations are relevant in the context of the ongoing trilogue negotiations on the NGT legislation among the three European institutions. The policy briefing clearly concludes that:
* Detection methods for NGT products are feasible, especially when developers of these GMOs provide the necessary genetic data, as required under the current EU legislation (Directive 2001/18/EC and Regulations 1829/2003 and 1830/2003)
* Mandating that developers of NGTs disclose a minimum level of genetic information would significantly reduce the cost and complexity of detection for enforcement authorities and food and feed operators. This would also accelerate the development of robust, science-based monitoring systems.
The DARWIN policy brief's conclusions and recommendations are in agreement with GMWatch's longstanding statements on the detection of new GMOs. The policy brief emphasises that reliable detection of NGT products is both feasible and essential for transparency and consumer trust. Achieving this, however, will require sustained investment, compliance with existing legislation, and mandatory disclosure of genetic information to enable cost-effective monitoring and robust traceability.
Read and download the policy briefing here.
Read the DARWIN researchers' first peer-reviewed paper on their findings here.
Main source: DARWIN
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