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News and comment on genetically modified foods and their associated pesticides    
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INTRODUCTION TO GM

GMO Myths and Facts front page.jpg

SCIENCE SUPPORTS REGULATION OF GENE EDITING

Plant tissue cultures

GENE EDITING: UNEXPECTED OUTCOMES AND RISKS

Damaged DNA on fire

GENE EDITING MYTHS AND REALITY

A guide through the smokescreen

Gene Editing Myths and Reality

ON-TARGET EFFECTS OF GENE EDITING

Damaged DNA

Nature resists GE - Nature

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Published: 16 June 2001
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Gene silencing is a plant's adaptive defence against unwelcome invasive elements

"Many of the details and ramifications have yet to be determined, but the current picture is that of a wonderfully elegant system that can generically recognize invading viruses and transposable elements (TEs) and marshal the plant's defences against them."
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Gene silencing as an adaptive defence against viruses
June 15, 2001
Nature
411, 834 - 842
Peter M. Waterhouse, Ming-Bo Wang & Tony Lough

Abstract -- Gene silencing was perceived initially as an unpredictable and inconvenient side effect of introducing transgenes into plants. It now seems that it is the consequence of accidentally triggering the plant's adaptive defence mechanism against viruses and transposable elements. This recently discovered mechanism, although mechanistically different, has a number of parallels with the immune system of mammals.

Biology students are taught that the concept of vaccination came from Edward Jenner's discovery that milkmaids and dairymen infected with the mild cowpox virus were protected against smallpox. It is less widely appreciated that plants can also be protected from a severe virus by prior infection with a mild strain of a closely related virus. This cross protection in plants was recognized as early as the 1920s, but its mechanism has been a mystery - plants do not possess an antibody-based immune system analogous to that found in animals. This was probably the first observation of a plant's intrinsic defence mechanism against viruses which, 75 years later, is just beginning to be understood.

In the past decade, there has been considerable research into transgene-mediated virus resistance, co-suppression, virus-induced gene silencing (VIGS), antisense suppression and transcriptional gene silencing (TGS) in plants. There has also been intense research into RNA interference in Drosophila and nematodes, and quelling in fungi. These seemingly disparate endeavours have produced pieces of a jigsaw puzzle which, when put together, begin to reveal the existence and characteristics of a natural defence system in plants against viruses and transposable DNA elements.

Many of the details and ramifications have yet to be determined, but the current picture is that of a wonderfully elegant system that can generically recognize invading viruses and transposable elements (TEs) and marshal the plant's defences against them. 

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